Management of Protease Inhibitor--Associated Diarrhea
نویسندگان
چکیده
منابع مشابه
Mechanisms and management of antibiotic-associated diarrhea.
Only 10%-20% of all cases of antibiotic-associated diarrhea (AAD) are caused by infection with Clostridium difficile. Other infectious organisms causing AAD include Clostridium perfringens, Staphylococcus aureus, Klebsiella oxytoca, Candida species, and Salmonella species. Most of the clinically mild AAD cases are due to functional disturbances of intestinal carbohydrate or bile acid metabolism...
متن کاملFunctional Analysis of a Missense Mutation in the Serine Protease Inhibitor SPINT2 Associated with Congenital Sodium Diarrhea
Membrane-bound serine proteases play important roles in different biological processes. Their regulation by endogenous inhibitors is poorly understood. A Y163C mutation in the SPINT2 gene encoding the serine protease inhibitor Hepatocyte Growth Factor Inhibitor HAI-2 is associated with a congenital sodium diarrhea. The functional consequences of this mutation on HAI-2 activity and its physiolog...
متن کاملThe management of HIV-1 protease inhibitor pharmacokinetic interactions.
The HIV-1 protease inhibitors (PIs) are widely used in combination antiretroviral therapy for the management of HIV-1 infection. Certain characteristics of the PIs, in particular their metabolism being mainly via the cytochrome P450 isoenzyme group and their gastric absorption being pH dependent, make them prone to clinically significant drug interactions with other antiretrovirals, concomitant...
متن کاملOtotoxicity may be associated with protease inhibitor therapy.
ciency. Pregnant women who have iron deficiency are at higher risk for preterm birth, a low-birth-weight infant, and maternal death, which are factors that must be considered in balancing the potential risks and benefits of iron supplementation during HIV infection [3]. In developed countries, the epidemiology of anemia, nutritional status, and oxidative stress has changed with the advent of hi...
متن کاملPrevalence and management of antibiotic associated diarrhea in general hospitals
BACKGROUND Antibiotic-associated diarrhea (AAD) is a common adverse effect of antibiotic (AB) treatment. This study aimed to measure the overall prevalence of AAD (including mild to moderate diarrhea) in hospitalized AB treated patients, to investigate associated risk factors and to document AAD associated diagnostic investigations, contamination control and treatment. METHODS During 8 observ...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2000
ISSN: 1058-4838,1537-6591
DOI: 10.1086/313826